Affiliation:
1. State Key Laboratory of Southwestern Chinese Medicine Resources, and School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, and CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy
of Sciences, Kunming, China
3. Institute of Applied Chemistry, Jiangxi Academy of Sciences, Nanchang, China
Abstract
AbstractCamptothecin (CPT) and its derivatives have attracted worldwide attention because of their notable anticancer activity. However, the growing demand for CPT in the global pharmaceutical
industry has caused a severe shortage of CPT-producing plant resources. In this study, phytochemical analysis of Nothapodytes tomentosa results in the isolation and identification of
CPT (13) and 16 analogues (1 – 12, 14 – 17), including a new (1) and five known (9, 10, 12, 15, and 17) CPT analogues with an open E-ring. In
view of the potential anticancer activity of CPT analogues with an open E-ring, the fragmentation pathways and mass spectra profiles of these six CPT analogues (1, 9, 10, 12, 15, and
17) are investigated, providing a reference for the rapid detection of these compounds in other plants. Furthermore, based on the fragmentation patterns of CPT (13) and known
analogues (2 – 8, 11, 14, 16, 18 – 26), the distribution and content of these compounds in different tissues of N. tomentosa, N. nimmoniana, Camptotheca
acuminata, and Ophiorrhiza japonica are further studied. Our findings not only provide an alternative plant resource for further expanding the development and utilization of CPT
and its analogues, but also lay a foundation for improving the utilization of known CPT-producing plant resources.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Xinglin Scholar Research Promotion Project of Chengdu University of TCM
National Key R&D Program of China
Subject
Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry
Cited by
1 articles.
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