The Effect of Asthma Severity on Perinatal Outcomes: A Tertiary Hospital Experience

Author:

Tanacan Atakan1ORCID,Fadiloglu Erdem1ORCID,Celebioglu Ebru Damadoglu2,Orhan Nazli1,Unal Canan1,Celik Tolga3,Kalyoncu Ali Fuat2,Beksac Mehmet Sinan1

Affiliation:

1. Department of Obstetric and Gynecology, Division of Perinatology, Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey

2. Division of Allergic and Immunological Diseases, Department of Chest Disease, Hacettepe Universitesi Tip Fakultesi, Ankara

3. Division of Neonatology, Department of Pediatrics, Hacettepe Universitesi Tip Fakultesi, Ankara

Abstract

Abstract Objective To evaluate the effect of asthma severity and disease exacerbation on pregnancy outcomes. Materials and Methods Pregnancies were classified into 3 groups as mild (n=195), moderate (n=63), and severe (n=26) according to preconceptional asthma severity. Demographic features, clinical characteristics, and perinatal outcomes were compared between the groups. Delivery characteristics and pregnancy outcomes were also compared between the pregnancies with or without asthma exacerbation (43 and 241 pregnancies, respectively). Results Worsening of symptoms during pregnancy was higher in moderate and severe asthma groups (p<0.001). Rates of spontaneous abortion, fetal structural anomaly, preterm delivery, preeclampsia, fetal growth restriction (FGR), oligohydramnios, gestational diabetes, and intrauterine fetal demise were higher in moderate and severe asthma groups (p-values were < 0.001, 0.01, 0.008, 0.02, 0.01, < 0.001, < 0.001, and 0.007, respectively). Admissions to neonatal intensive care units and neonatal complication rates were higher among moderate and severe asthma groups (p=0.035 and < 0.001). Spontaneous abortion, preterm delivery, preeclampsia, FGR, oligohydramnios, and neonatal complication rates were higher (p<0.001) in the group with exacerbated symptoms. Conclusion Moderate to severe asthma before pregnancy and the exacerbation of asthma symptoms during pregnancy may lead to increased rates of perinatal complications.

Publisher

Georg Thieme Verlag KG

Subject

Maternity and Midwifery,Obstetrics and Gynaecology,Pediatrics, Perinatology, and Child Health

Reference31 articles.

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2. Spirometry is related to perinatal outcomes in pregnant women with asthma;M Schatz;Am J Obstet Gynecol,2006

3. The change of asthma course during pregnancy;J C Gluck;Clin Rev Allergy Immunol,2004

4. Asthma morbidity during pregnancy can be predicted by severity classification;M Schatz;J Allergy Clin Immunol,2003

5. Severe asthma exacerbations during pregnancy;V E Murphy;Obstet Gynecol,2005

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