Affiliation:
1. State Key Laboratory of Drug Research
2. Shenzhen Grubbs Institute and Department of Chemistry
Abstract
A rhodium-catalyzed enantioselective addition of glyoxylates to arylboronic acids promoted by a simple chiral sulfinamide-based olefin ligand under mild reaction conditions is described. The reaction provides access to a variety of optically active substituted mandelic acid esters in good yields with up to 83% ee. The catalytic system is also applicable to pyruvate addition. The synthetic utility of this method is highlighted by a formal synthesis of the antiplatelet drug clopidogrel.
Funder
National Major Science and Technology Projects of China
National Natural Science Foundation of China
Cited by
4 articles.
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