Methylglyoxal and Advanced Glycation End Products in Patients with Diabetes – What We Know so Far and the Missing Links-Reference-Cited by-同舟云学术

Methylglyoxal and Advanced Glycation End Products in Patients with Diabetes – What We Know so Far and the Missing Links

Published:2017-04-13 Issue:08 Volume:127 Page:497-504
ISSN:0947-7349
Container-title:Experimental and Clinical Endocrinology & Diabetes
language:en
Short-container-title:Exp Clin Endocrinol Diabetes

Author:

Groener Jan Benedikt¹,Oikonomou Dimitrios¹,Cheko Ruan¹,Kender Zoltan¹,Zemva Johanna¹,Kihm Lars¹,Muckenthaler Martina²,Peters Verena³,Fleming Thomas¹,Kopf Stefan¹,Nawroth Peter P.¹

Affiliation:

1. Department Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany

2. Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and University of Heidelberg, Heidelberg, Germany

3. University Children’s Hospital, University of Heidelberg, Heidelberg, Germany

Abstract

AbstractHyperglycemia explains the development of late diabetic complications in patients with diabetes type 1 and type 2 only partially. Most therapeutic efforts relying on intensive glucose control failed to decrease the absolute risk for complications by more than 10%, especially in patients with diabetes type 2. Therefore, alternative pathophysiological pathways have to be examined, in order to develop more individualized treatment options for patients with diabetes in the future. One such pathway might be the metabolism of dicarbonyls, among them methylglyoxal and the accumulation of advanced glycation end products. Here we review currently available epidemiological data on dicarbonyls and AGEs in association with human diabetes type 1 and type 2.

Publisher

Georg Thieme Verlag KG

Subject

Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0043-106443.pdf

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