Affiliation:
1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2. Experiment Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Abstract
Abstract
Swertia cincta, a plant of the genus Swertia in Gentianceae, has “heat-clearing” and detoxifying effects that normalize the gallbladder function in the treatment of jaundice.
Although numerous studies on Swertia cincta have been performed, the absorption and pharmacokinetic behaviors remain unclear. In this study, the compounds of Swertia cincta in
serum, bile, feces, and urine of rats were analyzed using a ultra-high-performance liquid chromatography-tandem mass spectrometry. A total of 9 prototype components and 48 metabolites were
detected in biological samples. Furthermore, we determined the main components absorbed in the blood of Swertia cincta and established a method for simultaneously determining these
components (sweroside, swertiamarin, and gentiopicroside) in positive ionization mode within 6 min. The quantitative method was successfully applied for the multiple-component
pharmacokinetic study of Swertia cincta.
Funder
National Scientific and Technological Major Special Project of China
Natural Science Foundation of Shanghai
National Natural Science Foundation of China
Subject
Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry
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