Affiliation:
1. Department of Ultrasound, First People’s Hospital of Foshan,
Foshan, China
2. Zhuhai Campus, Zunyi Medical University, Zunyi, China
Abstract
AbstractTo study risk factors for central lymph node metastasis (CLNM) in papillary
thyroid cancer (PTC) using the Chinese Thyroid Imaging Reporting and Data System
(C-TIRADS). We retrospectively analysed patients who underwent PTC surgery and
central lymph node dissection at First People’s Hospital of Foshan City.
The clinical and ultrasonic data of the patients from 1150 cases were analysed
by multivariate regression to evaluate the correlation between grayscale
ultrasound (US) features, C-TIRADS score, and the classification of thyroid
nodules and CLNM of PTCs. The C-TIRADS score was 3.0±1.0 in the CLNM
group, which was higher than that in the non-CLNM group (p<0.001). Sex
(male) (OR=1.586, 95% CI 1.232–2.042, p<0.001),
age (≤45 years) (OR=1.508, 95% CI 1.184–1.919,
p=0.001), location of nodes (lower pole) (OR=2.193, 95%
CI 1.519–3.166, p<0.001), number (multifocal) (OR=2.204,
95% CI 1.227–2.378, p<0.001), microcalcification
(OR=1.610, 95% CI 2.225–4.434, p=0.002),
extrathyroidal extension (OR=2.204, 95% CI 1.941–3.843,
p<0.001), maximum diameter of nodule (≥20 mm)
(OR=3.211, 95% CI 2.337–4.411, p<0.001), and
C-TIRADS score (OR=1.356, 95% CI 1.204–1.527,
p<0.001) were PTC in independent risk factors for CLNM. The C-TIRADS
score of PTC combined with the location, number, size, and ultrasound features
of the lesion and the patient’s sex and age are important in predicting
whether they present with CLNM and provide a reference basis for the clinical
formulation of a reasonable surgical treatment plan.
Funder
Medical Scientific Research Foundation of Guangdong Province of China
Project of Foshan "Fourteen Five" Medicine High-level Key Specialty Construction
Medical Scientific Research Foundation of Guangdong Province of China.
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism