Thyroid-Related Hormones Changes Predict Changes in Anthropometric
Measures and Incidence of Obesity in Chinese Euthyroid Persons
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Published:2023-08-09
Issue:10
Volume:55
Page:684-691
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ISSN:0018-5043
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Container-title:Hormone and Metabolic Research
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language:en
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Short-container-title:Horm Metab Res
Author:
Deng Ling12ORCID,
Zheng Xiaoxia2,
Shuai Ping2,
Yu Xijie1
Affiliation:
1. Laboratory of Endocrinology and Metabolism, West China Hospital,
Sichuan University, Chengdu, China
2. Department of Health Management & Institute of Health
Management, Sichuan Provincial People’s Hospital, University of
Electronic Science and Technology of China, Chengdu, China
Abstract
AbstractThe purpose of this study was to investigate the correlation of thyroid-related
hormones changes within the reference range with the changes in anthropometric
measures and incidence of obesity. The study included 4850 subjects with normal
thyroid-related hormones at baseline and at follow-up. We evaluated the
relationship of changes in thyroid-related biomarkers with anthropometric
measures changes and incidence of obesity. In euthyroid persons, changes in
serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free
thyroxine (FT4) concentrations and FT3/FT4 ratio were independent
predictors of changes in body mass index (BMI) and waist circumference (WC) in
men, changes in serum FT3 and FT4 concentrations and FT3/FT4 ratio were
independent predictors of changes in BMI and WC in women. Every single unit
increment in ΔFT3/FT4 was accompanied by a 7.144 and 7.572 times
risk of having obesity in men and women, respectively. Every single unit
decrement in ΔFT4 was accompanied by a 21.0% and 26.9%
lower risk of having obesity in men and women, respectively. In conclusion, in
euthyroid individuals, changes in thyroid-related hormones were associated with
anthropometric measures changes and incidence of obesity.
Funder
the 1.3.5 project for discipline of excellence, West China Hospital, Sichuan University
National Natural Science Foundation of China
Department of Science and Technology of Sichuan Province
the Sichuan University
Chengdu Bureau of Science and Technology
Publisher
Georg Thieme Verlag KG
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism