Serum Progesterone is Negatively Associated with Hypertension and Blood Pressure Indicators Among Men and Postmenopausal Women

Author:

Shi Jiayu1,Wei Dandan1,Wang Lulu1,Xu Qingqing1,Wang Juan1,Ma Cuicui1,Geng Jintian1,Zhao Mengzhen1,Huo Wenqian2,Linlin Li1,Wang Chongjian1,Fan Caini3,Mao Zhenxing1

Affiliation:

1. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China

2. Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou University, Zhengzhou, China

3. Department of Hypertension, Henan Provincial People’s Hospital, Zhengzhou, China

Abstract

AbstractSex hormones have been shown to be negatively associated with hypertension, but the relationship between serum progesterone levels and hypertension has not been adequately studied. Therefore, we aimed to evaluate the association between progesterone and hypertension among Chinese rural adults. A total of 6222 participants were recruited, which included 2577 men and 3645 women. The concentration of serum progesterone was detected by liquid chromatography-mass spectrometer system (LC-MS/MS). Logistic regression and linear regression were used to assess the associations between progesterone levels and hypertension and blood pressure related indicators, respectively. Constrained splines were used to fit the dose-response relationships of progesterone with hypertension and blood pressure related indicators. Moreover, the interactive effects of several lifestyle factors and progesterone were identified by a generalized linear model. After fully adjusting the variables, progesterone levels were inversely associated with hypertension in men [odds ratio (OR): 0.851, 95% confidence interval (CI): 0.752, 0.964]. Among men, a 2.738 ng/ml increase in progesterone was associated with a 0.557 mmHg decrease in diastolic blood pressure (DBP) (95% CI: –1.007, –0.107) and a 0.541 mmHg decrease in mean arterial pressure (MAP) (95% CI: –1.049, –0.034), respectively. Similar results were observed in postmenopausal women. Interactive effect analysis showed that only a significant interaction was observed between progesterone and educational attainment on hypertension in premenopausal women (p=0.024). Elevated levels of serum progesterone were associated with hypertension in men. Except for premenopausal women, a negative association of progesterone with blood pressure related indicators was observed.

Publisher

Georg Thieme Verlag KG

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism

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