Selectivity: A Goal for Synthetic Economy

Abstract

AbstractChemical reactivity plays a major role in understanding several aspects of selectivity. Therefore, in this account, we present a plethora of reactions that demonstrate our efforts in exploiting interesting cases of selectivity over the past three decades. Among them, chemoselectivity, regioselectivity and stereoselectivity are discussed. Strain, steric factors, and separation of the reacting functionalities are revealed as prominent features in generating selectivity.1 Introduction2 Chemoselectivity3 Regioselectivity4 Diastereoselectivity5 Substrate-Based Selectivity6 Reagent-Based Selectivity7 Steric-Volume-Induced Selectivity8 Role of Temperature and Reaction Time in Achieving Selectivity9 Role of the Catalyst in Observing Selectivity10 Separation as a Parameter for Selectivity11 pK a (Acidity of the Active Methylene Component)12 Sequence as a Tool for Selectivity13 Strain of the Ring System14 Examples of Miscellaneous Selectivity15 Conclusions