Facile Access to Amido (Thio)xanthates under Eco-Friendly Conditions by One-Pot Three-Component Reaction (3-CR)

Author:

Franz Max1,Stalling Timo1,Schaper Raoul1,Schmidtmann Marc1,Martens Jürgen1

Affiliation:

1. Institute of Chemistry, University of Oldenburg

Abstract

A straightforward three-component reaction (3-CR) for the preparation of a variety of biologically interesting amido (thio)xanthates has been developed. By the proper choice of a potassium (thio)xanthate salt, a cyclic or acyclic imine, and an acyl chloride as substrates a broad scope with respect to the substituents can be realized. This operationally simple one-pot method proceeds under mild and environmentally friendly conditions while potassium chloride is produced as the single waste-product.

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

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