40.1.1.5.2.4 The Mannich Reaction (Update 2017)

Abstract

AbstractThe Mannich reaction, one of the most fundamental C—C bond-forming reactions, is more than 100 years old and yet is still fascinating. This chapter is an update to the earlier Science of Synthesis contribution (Section 40.1.1.5.2) describing methods for the asymmetric synthesis of highly versatile β-amino carbonyl compounds and derivatives via Mannich reaction. This review predominantly focuses on recent developments in catalytic enantioselective and diastereoselective processes of direct, indirect, and vinylogous Mannich reactions using both metal-based catalysts as well as organocatalysts.