Copper-Catalyzed Carbonylation Reactions: A Personal Account

Abstract

AbstractCarbonylation reactions have been widely used to construct carbonyl-containing molecules or carbon enhancement reactions, which are mostly catalyzed by noble metals (Pd, Rh, Ru, Ir). In this review, we introduce the copper-catalyzed carbonylation reactions that have been developed in our group. Diverse reactions have been developed using various substrates, including the carbonylation of C–H activated alkanes, the difunctionalization of unsaturated C–C bonds, and the carbonylation of alkyl halides via the radical pathway.1 Introduction2 Cu-Catalyzed Carbonylation of C(sp 3)–H Bonds3 Cu-Catalyzed Carbonylative Difunctionalization of Unsaturated Bonds4 Cu–X (H or B) Mediated Acylation of Unsaturated Bonds with Electrophiles5 Cu–X (H or B) Mediated Carbonylation of Unsaturated Bonds6 Cu-Catalyzed Carbonylation of Alkyl Halides7 Other Types of Copper-Catalyzed Carbonylation Reactions8 Conclusion and Outlook