Affiliation:
1. Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University
2. Faculty of Pharmaceutical Sciences, Toho University
Abstract
AbstractA dehydrative esterification from an equimolar mixture of carboxylic acids and primary or secondary alcohols in toluene at 100 °C was promoted without the necessity to remove water by using a simple 2,2′-biphenol-derived phosphoric acid catalyst (2.5–10 mol%). This reaction was also successfully conducted at the gram scale. To demonstrate the synthetic utility of this catalytic system, pharmaceutically useful substrates and acid-sensitive substrates were examined using these acid–base cooperative phosphoric acid catalysts, which exhibit relatively weak Brønsted acidity.
Funder
Japan Society for the Promotion of Science, KAKENHI
Hyogo Science and Technology Association