Affiliation:
1. Zhejiang Provincial Key Laboratory for Chemical & Biological Processing Technology of Farm Products School of Biological & Chemical Engineering, Zhejiang University of Science and Technology
2. College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University
Abstract
AbstractA direct oxidative alkylarylation reaction of N-arylacrylamides with simple alkanes for the synthesis of 3,3-disubstituted oxindoles under metal-free conditions was demonstrated. By using PhI(OAc)2 [(diacetoxy)iodobenzene] as an oxidant, a series of 3,3-disubstituted oxindoles bearing different aryl or alkyl substituents were generated in moderate to excellent chemical yields via a radical-initiated alkylation/cyclization process. The reported method features good functional group tolerance and wide substrate range, and provides an effective method for the preparation of various alkyl substituted 3,3-disubstituted oxindoles.
Funder
Basic Public Welfare Research Program of Zhejiang Province
Subject
Organic Chemistry,Materials Science (miscellaneous),Biomaterials,Catalysis