Synthesis of Chiral Amines by C–C Bond Formation with Photoredox Catalysis

Abstract

AbstractChiral amines are key substructures of biologically active natural products and drug candidates. The advent of photoredox catalysis has changed the way synthetic chemists think about building these substructures, opening new pathways that were previously unavailable. New developments in this area are reviewed, with an emphasis on C–C bond constructions involving radical intermediates generated through photoredox processes.1 Introduction2 Radical–Radical Coupling of α-Amino Radicals2.1 Radical–Radical Coupling Involving Amine Oxidation2.2 Radical–Radical Coupling Involving Imine Reduction2.3 Couplings Involving both Amine Oxidation and Imine Reduction3 Addition Reactions of α-Amino Radicals3.1 Conjugate Additions of α-Amino Radicals3.2 Addition of α-Amino Radicals to Heteroaromatic Systems3.3 Cross Coupling via Additions to Transition Metal Complexes4 Radical Addition to C=N Bonds Using Photoredox Catalysis4.1 Intramolecular Radical Addition to C=N Bonds4.2 Intermolecular Radical Addition to C=N Bonds5 Conclusion