Activated neutrophils exert myeloid-derived suppressor cell activity damaging T cells beyond repair-Reference-Cited by-同舟云学术

Activated neutrophils exert myeloid-derived suppressor cell activity damaging T cells beyond repair

Published:2019-11-18 Issue:22 Volume:3 Page:3562-3574
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Aarts Cathelijn E. M.¹,Hiemstra Ida H.¹,Béguin Eelke P.²,Hoogendijk Arjan J.²,Bouchmal Souhailla¹,van Houdt Michel¹,Tool Anton T. J.¹,Mul Erik³,Jansen Machiel H.⁴,Janssen Hans⁵,van Alphen Floris P. J.³,de Boer Jan-Paul⁶,Zuur Charlotte L.⁷,Meijer Alexander B.²³,van den Berg Timo K.¹,Kuijpers Taco W.¹⁸

Affiliation:

1. Department of Blood Cell Research, Sanquin Research, Amsterdam University Medical Center (AUMC), University of Amsterdam, Amsterdam, The Netherlands;

2. Department of Molecular and Cellular Hemostasis and

3. Department of Research Facilities, Sanquin Research, Amsterdam, The Netherlands;

4. Department of Experimental Immunology, AUMC, Amsterdam, The Netherlands;

5. Department of Biochemistry,

6. Department of Medical Oncology, and

7. Department of Head and Neck Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands; and

8. Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children’s Hospital, AUMC, University of Amsterdam, Amsterdam, The Netherlands

Abstract

Key Points Activated neutrophils can suppress T-cell proliferation in a CD11b-dependent multistep process involving ROS production and degranulation. MDSC activity results in nonapoptotic T-cell damage.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/22/3562/1540338/advances031609.pdf

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