Dock8 regulates BCR signaling and activation of memory B cells via WASP and CD19-Reference-Cited by-全球学者库

Dock8 regulates BCR signaling and activation of memory B cells via WASP and CD19

Published:2018-02-22 Issue:4 Volume:2 Page:401-413
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Sun Xiaoyu¹²³⁴,Wang Jinzhi¹²³⁴,Qin Tao¹²³⁴,Zhang Yongjie⁵,Huang Lu¹²³⁴,Niu Linlin¹²³⁴,Bai Xiaoming⁶,Jing Yukai⁷,Xuan Xingtian¹²³⁴,Miller Heather⁸,Zhao Yao¹²³⁴,Song Wenxia⁹,Tang Xuemei¹²³⁴,Zhang Zhiyong¹²³⁴,Zhao Xiaodong¹²³⁴,Liu Chaohong¹²³⁴⁷

Affiliation:

1. Chongqing Key Laboratory of Child Infection and Immunity,

2. Department of Pediatric Research Institute,

3. Ministry of Education Key Laboratory of Child Development and Disorders,

4. International Science and Technology Cooperation Base of Child Development and Critical Disorders,

5. Department of Hematology and Oncology, and

6. Department of Dermatology, Children's Hospital of Chongqing Medical University, Chongqing, China;

7. Department of Pathogen Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China;

8. Department of Intracellular Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT; and

9. Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD

Abstract

Key Points Dock8 regulates the expression of CD19 and WASP. BCR clustering and B-cell spreading are decreased in memory B cells of Dock8 patients.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/4/401/880384/advances007880.pdf

Reference27 articles.

1. Cellular signaling of Dock family proteins in neural function;Miyamoto;Cell Signal,2010

2. Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology;Ruusala;FEBS Lett,2004

3. Combined immunodeficiency associated with DOCK8 mutations;Zhang;N Engl J Med,2009

4. Hyper-IgE syndromes;Grimbacher;Immunol Rev,2005

5. Extreme hyperimmunoglobulinemia E and undue susceptibility to infection;Buckley;Pediatrics,1972

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