Haploidentical HSCT for hemoglobinopathies: improved outcomes with TCRαβ+/CD19+-depleted grafts-Reference-Cited by-同舟云学术

Haploidentical HSCT for hemoglobinopathies: improved outcomes with TCRαβ+/CD19+-depleted grafts

Published:2018-02-05 Issue:3 Volume:2 Page:263-270
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Gaziev Javid¹,Isgrò Antonella¹,Sodani Pietro²,Paciaroni Katia¹,De Angelis Gioia¹,Marziali Marco¹,Ribersani Michela¹,Alfieri Cecilia¹,Lanti Alessandro³,Galluccio Tiziana¹,Adorno Gaspare³,Andreani Marco¹

Affiliation:

1. International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinico Tor Vergata, Rome, Italy;

2. Unità Operativa Complessa Internal Medicine and Hematology, Azienda Ospedaliera Ospedali Riuniti Marche Nord, Ospedale Santo Croce, Fano, Italy; and

3. Servizio di Immunoematologia e Medicina Trasfusionale, Policlinico Tor Vergata Foundation, Rome, Italy

Abstract

Key Points TCRαβ+/CD19+-depleted haplo-HCT is associated with a reduced incidence of graft failure in patients with hemoglobinopathies. The major challenges of haplo-HCT in hemoglobinopathies are delayed immune reconstitution and associated morbidity and mortality.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/3/263/880049/advances012005.pdf

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