Clinical, molecular, and immunological responses to pembrolizumab treatment of synchronous melanoma and acute myeloid leukemia

Author:

Kubasch Anne Sophie12,Wehner Rebekka3456,Bazzurri Serena7,Tunger Antje34,Stasik Sebastian2,Garzarolli Marlene8,Meinel Jörn9,Baretton Gustavo4569,Meier Friedegund4568,Thiede Christian2456,Schmitz Marc3456,Platzbecker Uwe12456

Affiliation:

1. Center for Rare Diseases, University Hospital Carl Gustav Carus,

2. Medical Clinic and Policlinic I, University Hospital Carl Gustav Carus,

3. Institute of Immunology, Medical Faculty Carl Gustav Carus, and

4. National Center for Tumor Diseases, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany;

5. German Cancer Consortium, Dresden, Germany;

6. German Cancer Research Center, Heidelberg, Germany;

7. Department of Oncology, Santo Stefano Hospital, Prato, Italy; and

8. Department of Dermatology and

9. Institute of Pathology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Abstract

Key Points Pembrolizumab treatment of melanoma and concomitant sAML resulted in a significant platelet response and clearance of IDH1 mutation. Pembrolizumab therapy and response was associated with an increased PD-L1 expression on acute myeloid leukemia blasts and T cells.

Publisher

American Society of Hematology

Subject

Hematology

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