Mechanisms of establishment and functional significance of DNA demethylation during erythroid differentiation-Reference-Cited by-同舟云学术

Mechanisms of establishment and functional significance of DNA demethylation during erythroid differentiation

Published:2018-07-30 Issue:15 Volume:2 Page:1833-1852
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Bartholdy Boris¹^ORCID,Lajugie Julien¹,Yan Zi¹,Zhang Shouping¹,Mukhopadhyay Rituparna¹,Greally John M.²,Suzuki Masako²,Bouhassira Eric E.¹^ORCID

Affiliation:

1. Department of Cell Biology and

2. Department of Genetics, Albert Einstein College of Medicine, Bronx, NY

Abstract

Key Points We have generated allele-specific base resolution methylomes of primary basophilic erythroblasts. DNA demethylation during differentiation of HSPC into BasoE occurs mostly in inactive regions causing formation of PMD in 74% of methylome.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/15/1833/881698/advances015651.pdf

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