Clinical impact of BAALC expression in high-risk acute promyelocytic leukemia

Author:

Lucena-Araujo Antonio R.123,Pereira-Martins Diego A.123,Koury Luisa C.3,Franca-Neto Pedro L.1,Coelho-Silva Juan L.123,de Deus Wagatsuma Virginia M.23,Melo Raul A. M.4,Bittencourt Rosane5,Pagnano Katia6,Pasquini Ricardo7,Chiattone Carlos S.8,Fagundes Evandro M.9,Chauffaille Maria de Lourdes10,Schrier Stanley L.11,Tallman Martin S.12,Ribeiro Raul C.13,Grimwade David14,Ganser Arnold15,Löwenberg Bob16,Lo-Coco Francesco1718,Sanz Miguel A.1920,Berliner Nancy21,Rego Eduardo M.23ORCID

Affiliation:

1. Department of Genetics, Federal University of Pernambuco, Recife, Brazil;

2. Department of Internal Medicine, Medical School of Ribeirao Preto and

3. Center for Cell Based Therapy, University of São Paulo, Ribeirao Preto, Brazil;

4. Department of Internal Medicine, Federal University of Pernambuco, Recife, Brazil;

5. Hematology Division, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;

6. Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil;

7. Hematology Division, Federal University of Paraná, Curitiba, Brazil;

8. Hematology Division, Santa Casa Medical School, Sao Paulo, Brazil;

9. Hematology Division, Department of Internal Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil;

10. Division of Hematology, Federal University of Sao Paulo, Sao Paulo, Brazil;

11. Department of Medicine, Stanford University, Stanford, CA;

12. Leukemia Service, Memorial Sloan Kettering Cancer Center/Weill Cornell Medical College, New York, NY;

13. Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN;

14. Department of Medical and Molecular Genetics, School of Medicine, King’s College London, London, United Kingdom;

15. Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany;

16. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands;

17. Department of Biopathology, University Tor Vergata, Rome, Italy;

18. Santa Lucia Foundation, Rome, Italy;

19. Department of Hematology, Valencia University Medical School, Valencia, Spain;

20. Centro de Investigación Biomédica en Red de Cáncer, Instituto Carlos III, Madrid, Spain; and

21. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

Abstract

Key Points BAALC expression is significantly lower in APL compared with other subsets of AML and healthy volunteers. BAALC overexpression can independently predict shorter DFS in patients with high-risk disease.

Publisher

American Society of Hematology

Subject

Hematology

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