A cryptic imatinib-sensitive G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia-Reference-Cited by-同舟云学术

A cryptic imatinib-sensitive G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia

Published:2020-01-30 Issue:3 Volume:4 Page:445-448
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Jan Max¹²,Grinshpun Daniel E.²³,Villalba Julian A.¹^ORCID,Dal Cin Paola⁴⁵,Sykes David B.⁴⁶^ORCID,Iafrate A. John¹⁴,Ebert Benjamin L.²³⁴⁷,Hobbs Gabriela S.⁴⁸^ORCID,Nardi Valentina¹⁴

Affiliation:

1. Department of Pathology, Massachusetts General Hospital, Boston, MA;

2. Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA;

3. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

4. Harvard Medical School, Harvard University, Boston, MA;

5. Department of Pathology, Brigham and Women’s Hospital, Boston, MA;

6. Division of Hematology, Massachusetts General Hospital Cancer Center, Boston, MA;

7. Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Boston, MA; and

8. Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA

Abstract

Key Points Targeted RNA sequencing detected a cryptic G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia and normal FISH studies. Consistent with the patient’s response to imatinib, we demonstrate this rearrangement is oncogenic and sensitive to TKI in cell culture.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/4/3/445/1634288/advancesadv2019001182.pdf

Reference14 articles.

1. Myeloid neoplasms with eosinophilia;Reiter;Blood,2017

2. Imatinib in myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRB in chronic or blast phase;Jawhar;Ann Hematol,2017

3. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation;Golub;Cell,1994

4. Abnormalities of chromosome 12p13 and malignant proliferation of eosinophils: a nonrandom association;Keene;Br J Haematol,1987

5. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins;Carroll;Blood,1997

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Drug sensitivity profiling identifies potential therapies for myeloid neoplasm with eosinophilia driven by a novel G3BP1-PDGFRB fusion gene;Leukemia & Lymphoma;2023-12-29

2. Promoter swapping of truncated PDGFRB drives Ph-like acute lymphoblastic leukemia;npj Precision Oncology;2023-12-09

3. The international consensus classification of eosinophilic disorders and systemic mastocytosis;American Journal of Hematology;2023-06-07

4. False-Negative Testing for FIP1L1::PDGFRA by Fluorescence in situ Hybridization Is a Frequent Cause of Diagnostic Delay;Acta Haematologica;2023

5. Case of cryptic TNIP1::PDGFRB rearrangement presenting with myelodysplastic syndrome achieved hematologic and cytogenetic remission with low-dose imatinib plus decitabine therapy;Leukemia Research Reports;2023