Affiliation:
1. Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN 38101.
Abstract
Abstract
The t(2;5)(p23;q35) was detected in 9 of the 18 cases of large-cell lymphoma with an abnormal karyotype among 115 children with large-cell lymphoma treated at St Jude Children's Research Hospital from 1975 to 1993. When the cases containing the t(2;5) were classified according to the National Cancer Institute Working Formulation, 7 were large-cell, immunoblastic and 2 were diffuse large cell; according to the Kiel classification system, 6 were anaplastic large cell, 2 immunoblastic, and 1 centroblastic. CD30 expression was documented in 6 of 8 cases tested. All patients had nodal disease and 6 had extranodal involvement (bone in 4 cases and skin in 3). Eight of nine had advanced disease at diagnosis (stage Ill in 7 and stage IV in 1). Complete remission (CR) was attained in all patients and 6 remain in first CR for 19+ to 97+ months. Three relapsed, but successfully obtained second remissions; 2 are 58+ and 80+ months after retrieval therapy for local recurrences, and 1 patient died of recurrent disease. The t(2;5)(p23;q35) is associated with, but not limited to, anaplastic histology, a CD30+ T- cell phenotype, advanced stage disease with nodal (+/- extranodal) involvement, and chemosensitivity at diagnosis and relapse.
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Cited by
87 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Stem Cell Transplant for T Cell Non-Hodgkin Lymphoma;Basics of Hematopoietic Stem Cell Transplant;2023
2. Childhood Lymphoma;Abeloff's Clinical Oncology;2020
3. Cytogenetic analysis of hematologic malignant diseases;The AGT Cytogenetics Laboratory Manual;2017-03-04
4. PAEDIATRIC HAEMATOLOGICAL MALIGNANCIES: AN INCIDENCE AND CLINICOPATHOLOGICAL STUDY;Journal of Evolution of Medical and Dental Sciences;2016-08-26
5. T-cell Lymphomas;Surgical Pathology Clinics;2016-03