Genetic loss of SH2B3 in acute lymphoblastic leukemia

Author:

Perez-Garcia Arianne1,Ambesi-Impiombato Alberto1,Hadler Michael1,Rigo Isaura1,LeDuc Charles A.2,Kelly Kara2,Jalas Chaim3,Paietta Elisabeth4,Racevskis Janis4,Rowe Jacob M.56,Tallman Martin S.7,Paganin Maddalena8,Basso Giuseppe8,Tong Wei9,Chung Wendy K.2,Ferrando Adolfo A.1210

Affiliation:

1. Institute for Cancer Genetics, Columbia University, New York, NY;

2. Department of Pediatrics, Columbia University Medical Center, New York, NY;

3. Bonei Olam, Center for Rare Jewish Genetics Disorders, Brooklyn, NY;

4. Albert Einstein College of Medicine, New York, NY;

5. Technion, Israel Institute of Technology, Haifa, Israel;

6. Shaare Zedek Medical Center, Jerusalem, Israel;

7. Memorial Sloan-Kettering Cancer Center, New York, NY;

8. Hemato-Oncology Laboratory, Department of Pediatrics, University of Padua, Padua, Italy;

9. Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; and

10. Department of Pathology, Columbia University Medical Center, New York, NY

Abstract

Key Points SH2B3 is a recessive tumor suppressor gene with germline and somatic mutations in ALL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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