Inflammation, von Willebrand factor, and ADAMTS13-Reference-Cited by-同舟云学术

Inflammation, von Willebrand factor, and ADAMTS13

Published:2018-07-12 Issue:2 Volume:132 Page:141-147
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chen Junmei¹,Chung Dominic W.¹²^ORCID

Affiliation:

1. Bloodworks Research Institute, Seattle, WA; and

2. Department of Biochemistry, University of Washington, Seattle, WA

Abstract

Abstract Increasing evidence indicates that inflammation can cause thrombosis by a von Willebrand factor (VWF)-mediated mechanism that includes endothelial activation, secretion of VWF, assembly of hyperadhesive VWF strings and fibers, cleavage by ADAMTS13, and adhesion and deposition of VWF-platelet thrombi in the vasculature. This mechanism appears to contribute to thrombosis not only in small vessels, but also in large vessels. Inflammation and VWF contribute to atherogenesis and may contribute to arterial and venous thrombosis as well as stroke. Elucidation of the mechanism will hopefully identify new targets and suggest new approaches for prevention and intervention.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/2/141/1407123/blood769000.pdf

Reference89 articles.

1. von Willebrand’s disease and its correction with human plasma fraction 1-0;Nilsson;Acta Med Scand,1957

2. Cloning and characterization of two cDNAs coding for human von Willebrand factor;Sadler;Proc Natl Acad Sci USA,1985

3. von Willebrand factor, now cloned;Lynch;Br J Haematol,1986

4. Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization;Ginsburg;Science,1985

5. Structure of the gene for human von Willebrand factor;Mancuso;J Biol Chem,1989

Cited by 149 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Ambient PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) associated with pro-thrombotic biomarkers among young healthy adults: A 16 times repeated measurements panel study;Science of The Total Environment;2024-02

2. Persistent complement dysregulation with signs of thromboinflammation in active Long Covid;Science;2024-01-19

3. Von Willebrand factor promotes radiation-induced intestinal injury (RIII) development and its cleavage enzyme rhADAMTS13 protects against RIII by reducing inflammation and oxidative stress;Free Radical Biology and Medicine;2024-01

4. Palmitate Stimulates Expression of the von Willebrand Factor and Modulates Toll-like Receptors Level and Activity in Human Umbilical Vein Endothelial Cells (HUVECs);International Journal of Molecular Sciences;2023-12-23

5. ADAMTS13 in pediatric sepsis: a prognostic biomarker with potential therapeutic implications;Egyptian Pediatric Association Gazette;2023-12-20