Inflammation, von Willebrand factor, and ADAMTS13

Author:

Chen Junmei1,Chung Dominic W.12ORCID

Affiliation:

1. Bloodworks Research Institute, Seattle, WA; and

2. Department of Biochemistry, University of Washington, Seattle, WA

Abstract

Abstract Increasing evidence indicates that inflammation can cause thrombosis by a von Willebrand factor (VWF)-mediated mechanism that includes endothelial activation, secretion of VWF, assembly of hyperadhesive VWF strings and fibers, cleavage by ADAMTS13, and adhesion and deposition of VWF-platelet thrombi in the vasculature. This mechanism appears to contribute to thrombosis not only in small vessels, but also in large vessels. Inflammation and VWF contribute to atherogenesis and may contribute to arterial and venous thrombosis as well as stroke. Elucidation of the mechanism will hopefully identify new targets and suggest new approaches for prevention and intervention.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference89 articles.

1. von Willebrand’s disease and its correction with human plasma fraction 1-0;Nilsson;Acta Med Scand,1957

2. Cloning and characterization of two cDNAs coding for human von Willebrand factor;Sadler;Proc Natl Acad Sci USA,1985

3. von Willebrand factor, now cloned;Lynch;Br J Haematol,1986

4. Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization;Ginsburg;Science,1985

5. Structure of the gene for human von Willebrand factor;Mancuso;J Biol Chem,1989

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