Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas

Author:

Georgiou Konstantinos1,Chen Longyun12,Berglund Mattias3,Ren Weicheng1,de Miranda Noel F. C. C.4,Lisboa Susana5,Fangazio Marco6,Zhu Shida2,Hou Yong2,Wu Kui2,Fang Wenfeng7,Wang Xianhuo8,Meng Bin8,Zhang Li7,Zeng Yixin7,Bhagat Govind9,Nordenskjöld Magnus10,Sundström Christer11,Enblad Gunilla11,Dalla-Favera Riccardo6,Zhang Huilai8,Teixeira Manuel R.5,Pasqualucci Laura6,Peng Roujun7,Pan-Hammarström Qiang1ORCID

Affiliation:

1. Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Sweden;

2. BGI-Shenzhen, Shenzhen, China;

3. Department of Biosciences and Nutrition, Karolinska Institutet, Solna, Sweden;

4. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands;

5. Department of Genetics, Portuguese Oncology Institute, and Abel Salazar Biomedical Sciences Institute, Porto University, Porto, Portugal;

6. Institute for Cancer Genetics, Columbia University, New York, NY;

7. State Key Laboratory of Oncology in South China and Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China;

8. Department of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China;

9. Department of Pathology and Cell Biology, Columbia University, New York, NY;

10. Department of Molecular Medicine and Surgery, Karolinska Institutet and Karolinska University Hospital, Solna, Sweden; and

11. Department of Immunology, Genetics and Pathology, Rudbecklaboratoriet, Uppsala University, Uppsala, Sweden

Abstract

Key Points Translocations between PD-L1 and the IGH locus represent a genetic mechanism of PD-L1 overexpression in DLBCL. Genetic alterations in the PD-L1/PDL-2 locus are mainly associated with the non-GCB subtype of DLBCL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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