Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis

Author:

Teira Pierre1,Battiwalla Minoo2,Ramanathan Muthalagu3,Barrett A. John2,Ahn Kwang Woo45,Chen Min4,Green Jaime S.6,Saad Ayman7,Antin Joseph H.8,Savani Bipin N.9,Lazarus Hillard M.10,Seftel Matthew11,Saber Wael4,Marks David12,Aljurf Mahmoud13,Norkin Maxim14,Wingard John R.14,Lindemans Caroline A.15,Boeckh Michael16,Riches Marcie L.17,Auletta Jeffery J.18

Affiliation:

1. Sainte Justine Hospital, University of Montreal, Montreal, Quebec, Canada;

2. Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD;

3. Division of Hematology and Oncology, Department of Medicine, UMass Memorial Medical Center, Worcester, MA;

4. Center for International Blood and Marrow Transplant Research, Department of Medicine, and

5. Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI;

6. Division of Infectious Disease and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN;

7. Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL;

8. Center for Hematologic Oncology, Dana-Farber Cancer Institute, Boston, MA;

9. Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN;

10. Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH;

11. Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada;

12. Pediatric Bone Marrow Transplant, University Hospitals Bristol National Health Service Trust, Bristol, United Kingdom;

13. Department of Oncology, King Faisal Specialist Hospital Center & Research, Ridayh, Saudi Arabia;

14. Division of Hematology/Oncology, University Florida College of Medicine, Gainesville, FL;

15. Pediatric Blood and Marrow Transplantation Program, University Medical Center Utrecht, Utrecht, The Netherlands;

16. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

17. Division of Hematology/Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC; and

18. Host Defense Program, Divisions of Hematology/Oncology/Bone Marrow Transplant and Infectious Diseases, Nationwide Children’s Hospital, Columbus, OH

Abstract

Key Points Cytomegalovirus after bone marrow transplantation remains associated with lower survival but not prevention of leukemia relapse.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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