Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets-Reference-Cited by-同舟云学术

Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets

Published:2014-12-04 Issue:24 Volume:124 Page:3656-3665
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Pan Yanfang¹²³,Yago Tadayuki¹,Fu Jianxin¹⁴,Herzog Brett¹²,McDaniel J. Michael¹,Mehta-D’Souza Padmaja¹,Cai Xiaofeng¹,Ruan Changgeng⁴,McEver Rodger P.¹²,West Christopher²,Dai Kesheng⁴,Chen Hong¹²,Xia Lijun¹²⁴

Affiliation:

1. Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;

2. Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK;

3. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China;

4. Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China

Abstract

Key Points Sialylated O-glycans protects PDPN from proteolytic degradation. Sialylated core 1 O-glycans of PDPN on lymphatic endothelial cells (LECs) are required for interacting with platelets.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/24/3656/1382387/3656.pdf

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4. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema.;Schacht;EMBO J,2003

5. A mutant chaperone converts a wild-type protein into a tumor-specific antigen.;Schietinger;Science,2006

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