Single nucleotide variation in the TP53 3′ untranslated region in diffuse large B-cell lymphoma treated with rituximab-CHOP: a report from the International DLBCL Rituximab-CHOP Consortium Program

Author:

Li Yong12,Gordon Michael W.1,Xu-Monette Zijun Y.2,Visco Carlo3,Tzankov Alexander4,Zou Dehui5,Qiu Lugui5,Montes-Moreno Santiago6,Dybkaer Karen7,Orazi Attilio8,Zu Youli9,Bhagat Govind10,Richards Kristy L.11,Hsi Eric D.12,Choi William W. L.13,Han van Krieken J.14,Huang Qin15,Ai Weiyun16,Ponzoni Maurilio17,Ferreri Andrés J. M.17,Winter Jane N.18,Go Ronald S.19,Piris Miguel A.6,Møller Michael B.20,Wu Lin21,Wang Michael22,Ramos Kenneth S.1,Medeiros L. Jeffrey2,Young Ken H.2

Affiliation:

1. Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Brown Cancer Center, Louisville, KY;

2. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX;

3. Department of Hematology, San Bortolo Hospital, Vicenza, Italy;

4. Department of Pathology, University Hospital, Basel, Switzerland;

5. Institute of Hematology, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China;

6. Department of Pathology, Hospital Universitario Marqués de Valdecilla/IFIMAV, Santander, Spain;

7. Department of Hematology, Aarhus University Hospital, Aalborg, Denmark;

8. Department of Pathology, Weill Medical College of Cornell University, New York, NY;

9. Department of Pathology, The Methodist Hospital, Houston, TX;

10. Department of Pathology, Columbia University School of Medicine, New York, NY;

11. Department of Hematology, University of North Carolina School of Medicine, Chapel Hill, NC;

12. Department of Pathology, Cleveland Clinic, Cleveland, OH;

13. Department of Pathology, University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, China;

14. Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands;

15. Department of Pathology, City of Hope National Medical Center, Duarte, CA;

16. Department of Hematology, University of California San Francisco School of Medicine, San Francisco, CA;

17. Departments of Hematology and Pathology, San Raffaele H. Scientific Institute, Milan, Italy;

18. Department of Hematology, Feinberg School of Medicine, Northwestern University, Chicago, IL;

19. Department of Hematology, Gundersen Lutheran Health System, La Crosse, WI;

20. Department of Pathology, Odense University Hospital, Odense, Denmark;

21. Department of Genomic Oncology, Roche Molecular Systems Inc., Pleasanton, CA; and

22. Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX

Abstract

Key Points TP53 3′UTR variations demonstrate prognostic value in DLBCL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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