Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P)-Reference-Cited by-全球学者库

Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P)

Published:2013-08-01 Issue:5 Volume:122 Page:791-802
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhang Lin¹²³,Urtz Nicole¹,Gaertner Florian¹,Legate Kyle R.¹⁴,Petzold Tobias¹,Lorenz Michael¹,Mazharian Alexandra⁵,Watson Steve P.⁵,Massberg Steffen¹⁶

Affiliation:

1. Medizinische Klinik und Poliklinik I, Klinikum der Universität, Ludwig-Maximilians-Universität, Munich, Germany;

2. Heart Failure Institute, Research Center for Translational Medicine, and

3. Department of Cardiovascular Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China;

4. Center for NanoScience, Department of Applied Physics, Ludwig-Maximilians-Universität, Munich, Germany;

5. Centre for Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom; and

6. Deutsches Zentrum für Herz-Kreislaufforschung and Munich Heart Alliance, Munich, Germany

Abstract

Key Points Sphk2 provides a source of intracellular S1P that tightly controls thrombopoiesis by regulating SFK expression and activity in MKs. Modulation of intracellular S1P by regulating Sphk2 may provide a new strategy to enhance platelet production in patients with thrombocytopenia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/5/791/1374575/791.pdf

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