miR-28 regulates the germinal center reaction and blocks tumor growth in preclinical models of non-Hodgkin lymphoma-Reference-Cited by-同舟云学术

miR-28 regulates the germinal center reaction and blocks tumor growth in preclinical models of non-Hodgkin lymphoma

Published:2017-04-27 Issue:17 Volume:129 Page:2408-2419
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bartolomé-Izquierdo Nahikari¹,de Yébenes Virginia G.¹^ORCID,Álvarez-Prado Angel F.¹^ORCID,Mur Sonia M.¹,Lopez del Olmo Juan A.²^ORCID,Roa Sergio³^ORCID,Vazquez Jesus²⁴^ORCID,Ramiro Almudena R.¹^ORCID

Affiliation:

1. B Cell Biology Laboratory and

2. Cardiovascular Proteomics Laboratory, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain;

3. Division of Oncology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain; and

4. CIBER de Enfermedades Cardiovasculares, Madrid, Spain

Abstract

Key Points miR-28 is a regulator of the GC reaction that dampens B-cell receptor signaling and impairs B-cell proliferation and survival. miR-28 has antitumoral activity in BL and DLBCL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/17/2408/1400156/blood731166.pdf

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5. Molecular mechanisms of antibody somatic hypermutation;Di Noia;Annu Rev Biochem,2007

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