Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment

Author:

Shafat Manar S.1ORCID,Oellerich Thomas234,Mohr Sebastian2,Robinson Stephen D.5,Edwards Dylan R.56,Marlein Christopher R.1,Piddock Rachel E.1,Fenech Matthew67,Zaitseva Lyubov1,Abdul-Aziz Amina1,Turner Jeremy67,Watkins Johnathan A.8,Lawes Matthew9,Bowles Kristian M.19,Rushworth Stuart A.1

Affiliation:

1. Department of Molecular Haematology, Norwich Medical School, The University of East Anglia, Norwich Research Park, Norwich, United Kingdom;

2. Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany;

3. German Cancer Research Center and German Cancer Consortium, Heidelberg, Germany;

4. Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom;

5. School of Biological Sciences, and

6. Norwich Medical School, The University of East Anglia, Norwich Research Park, Norwich, United Kingdom;

7. Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospitals NHS Trust, Norwich, United Kingdom;

8. Pilar Research and Education, Cambridge, United Kingdom; and

9. Department of Haematology, Norfolk and Norwich University Hospitals NHS Trust, Norwich, United Kingdom

Abstract

Key Points Bone marrow adipocytes support AML survival. AML induces adipocyte lipolysis of triglyceride to free fatty acids and subsequent transport by FABP4.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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