A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value

Author:

Chen Wen-Lian12,Wang Jing-Han1,Zhao Ai-Hua13,Xu Xin1,Wang Yi-Huang12,Chen Tian-Lu13,Li Jun-Min1,Mi Jian-Qing1,Zhu Yong-Mei1,Liu Yuan-Fang1,Wang Yue-Ying1,Jin Jie4,Huang He5,Wu De-Pei6,Li Yan7,Yan Xiao-Jing7,Yan Jin-Song8,Li Jian-Yong9,Wang Shuai9,Huang Xiao-Jun10,Wang Bing-Shun11,Chen Zhu12,Chen Sai-Juan12,Jia Wei1312

Affiliation:

1. Key Laboratory of Systems Biomedicine of Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University (SJTU) and State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, SJTU School of Medicine, Shanghai, China;

2. Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China;

3. Center for Translational Medicine, Six People's Hospital, SJTU School of Medicine, Shanghai, China;

4. Zhejiang Institute of Hematology, and

5. Bone Marrow Transplantation Center, First Hospital, Zhejiang University School of Medicine, Hangzhou, China;

6. Jiangsu Institute of Hematology, First Hospital, Soochow University School of Medicine, Suzhou, China;

7. Department of Hematology, First Hospital of China Medical University, Shenyang, China;

8. Department of Hematology, Second Hospital, Dalian Medical University, Dalian, China;

9. Department of Hematology, First Hospital, Nanjing Medical University, Nanjing, China;

10. Institute of Hematology, Peking University and People's Hospital, Beijing, China;

11. Department of Biostatistics, SJTU School of Medicine, Shanghai, China; and

12. University of Hawaii Cancer Center, Honolulu, HI

Abstract

Key Points Acute myeloid leukemia (AML) patients present an altered glucose metabolism signature. A panel of 6 metabolite biomarkers involved in glucose metabolism are identified with prognostic value for cytogenetically normal AML.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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