Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke-Reference-Cited by-同舟云学术

Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke

Published:2015-02-19 Issue:8 Volume:125 Page:1325-1332
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wyseure Tine¹,Rubio Marina²^ORCID,Denorme Frederik³,Martinez de Lizarrondo Sara²,Peeters Miet¹,Gils Ann¹,De Meyer Simon F.³,Vivien Denis²,Declerck Paul J.¹^ORCID

Affiliation:

1. Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium;

2. INSERM Unité Mixte de Recherche Scientifique U919, Serine Proteases and Pathophysiology of the Neurovascular Unit, Université de Caen Basse Normandie, Groupement d'Intérêt Public Cyceron, Caen, France; and

3. Laboratory for Thrombosis Research, Katholieke Universiteit Leuven Kulak, Kortrijk, Belgium

Abstract

Key Points Early thrombolytic treatment with a bispecific inhibitor against TAFI and PAI-1 is effective without exogenous tPA. Even at the highest dose tested, the bispecific inhibitor against TAFI and PAI-1 does not prolong bleeding time.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/8/1325/1387791/1325.pdf

Reference58 articles.

1. Tissue at risk of infarction rescued by early reperfusion: a positron emission tomography study in systemic recombinant tissue plasminogen activator thrombolysis of acute stroke.;Heiss;J Cereb Blood Flow Metab,1998

2. Optimizing the management of acute ischaemic stroke: a review of the utilization of intravenous recombinant tissue plasminogen activator (tPA).;Eissa;J Clin Pharm Ther,2012

3. Thrombolysis in acute ischemic stroke: successes, failures, and new hopes.;Dávalos;Cerebrovasc Dis,2005

4. New insights into the molecular mechanisms of the fibrinolytic system.;Rijken;J Thromb Haemost,2009

5. Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor.;Bajzar;J Biol Chem,1995

Cited by 50 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. GPR55 Inactivation Diminishes Splenic Responses and Improves Neurological Outcomes in the Mouse Ischemia/Reperfusion Stroke Model;Cells;2024-02-03

2. Acute Ischemic Stroke Thrombus Composition;Neuroscience;2024-01

3. The fibrinolysis renaissance;Journal of Thrombosis and Haemostasis;2023-12

4. Brain Expression of CPB2 and Effects of Cpb2 Deficiency in Mouse Models of Behavior;Thrombosis and Haemostasis;2023-08-02

5. Composition and Organization of Acute Ischemic Stroke Thrombus: A Wealth of Information for Future Thrombolytic Strategies;Frontiers in Neurology;2022-07-06