Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia

Author:

Audrito Valentina12,Serra Sara12,Brusa Davide12,Mazzola Francesca3,Arruga Francesca12,Vaisitti Tiziana12,Coscia Marta4,Maffei Rossana5,Rossi Davide6,Wang Tao7,Inghirami Giorgio8910,Rizzi Menico11,Gaidano Gianluca6,Garcia Joe G. N.12,Wolberger Cynthia7,Raffaelli Nadia13,Deaglio Silvia12

Affiliation:

1. Department of Medical Sciences, University of Torino, Torino, Italy;

2. Immunogenetics Unit, Human Genetics Foundation, Torino, Italy;

3. Department of Clinical Sciences, Università Politecnica delle Marche, Ancona, Italy;

4. Division of Hematology, Department of Molecular Biotechnology and Health Sciences, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy;

5. Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy;

6. Division of Hematology, Department of Translational Medicine, “A. Avogadro” University of Eastern Piedmont, Novara, Italy;

7. Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD;

8. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY;

9. Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, Torino, Italy;

10. Department of Pathology and NYU Cancer Center, New York University School of Medicine, New York, NY;

11. Department of Pharmaceutical Sciences, “A. Avogadro” University of Eastern Piedmont, Novara, Italy;

12. Arizona Respiratory Center and Department of Medicine, The University of Arizona, Tucson, AZ; and

13. Department of Agricultural, Food and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy

Abstract

Key Points CLL lymphocytes show high intracellular and extracellular NAMPT levels, further increased upon activation. eNAMPT prompts differentiation of CLL monocytes into M2 macrophages that sustain CLL survival and reduce T-cell proliferation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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