Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo-Reference-Cited by-全球学者库

Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo

Published:2013-12-12 Issue:25 Volume:122 Page:4094-4106
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ma Dongying¹,Mizurini Daniella M.²,Assumpção Teresa C. F.¹,Li Yuan¹,Qi Yanwei³,Kotsyfakis Michail⁴,Ribeiro José M. C.¹,Monteiro Robson Q.²,Francischetti Ivo M. B.¹

Affiliation:

1. Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD;

2. Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;

3. Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; and

4. Institute of Parasitology, Biology Centre of the Academy of Sciences of Czech Republic, České Budějovice, Czech Republic

Abstract

Key Points Desmolaris, a major anticoagulant from vampire bat saliva, has been identified as a novel FXIa inhibitor. Desmolaris inhibits arterial thrombosis at concentrations that does not impair hemostasis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/25/4094/1371645/4094.pdf

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