N-WASP is required for B-cell–mediated autoimmunity in Wiskott-Aldrich syndrome

Author:

Volpi Stefano123ORCID,Santori Elettra2,Abernethy Katrina1,Mizui Masayuki4,Dahlberg Carin I. M.5ORCID,Recher Mike1,Capuder Kelly1,Csizmadia Eva6,Ryan Douglas1,Mathew Divij1,Tsokos George C.4,Snapper Scott78,Westerberg Lisa S.5,Thrasher Adrian J.9,Candotti Fabio2,Notarangelo Luigi D.110ORCID

Affiliation:

1. Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA;

2. Division of Immunology and Allergy, University Hospital of Lausanne, Laboratory Center of Epalinges, Lausanne, Switzerland;

3. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa and Unità Operativa Pediatria 2, Istituto Giannina Gaslini, Genoa, Italy;

4. Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA;

5. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden;

6. Transplantation Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA;

7. Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, Boston, MA;

8. Gastroenterology Division, Boston Children’s Hospital, Harvard Medical School, Boston, MA;

9. Centre for Immunodeficiency, Section of Molecular and Cellular Immunology, Institute of Child Health and Great Ormond Street Hospital for Children, National Health Service Foundation Trust, London, United Kingdom; and

10. Harvard Stem Cell Institute, Boston, MA

Abstract

Key Points Mice lacking both WASP and N-WASP in B lymphocytes have impaired response to T-cell-dependent antigens and defective B-cell activation. Deletion of N-WASP in B cells attenuates autoimmunity in WASP-deficient mice.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Cited by 24 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3