Solution structure of the major factor VIII binding region on von Willebrand factor-Reference-Cited by-同舟云学术

Solution structure of the major factor VIII binding region on von Willebrand factor

Published:2014-06-26 Issue:26 Volume:123 Page:4143-4151
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Shiltagh Nuha¹,Kirkpatrick John¹,Cabrita Lisa D.¹,McKinnon Tom A. J.²,Thalassinos Konstantinos¹,Tuddenham Edward G. D.¹³,Hansen D. Flemming¹

Affiliation:

1. Division of Biosciences, Institute of Structural and Molecular Biology, University College London, London, United Kingdom;

2. Department of Haematology, Hammersmith Hospital Campus, Imperial College London, London, United Kingdom; and

3. Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free Hospital NHS Trust, London, United Kingdom

Abstract

Key PointsThe high-resolution structure of the complex disulfide-bonded TIL′E′ (D′) region of VWF is presented. The major factor VIII binding site is localized around a flexible region on the TIL′ domain.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/26/4143/1378432/4143.pdf

Reference48 articles.

1. Response to infusions of polyelectrolyte fractionated human factor VIII concentrate in human haemophilia A and von Willebrand’s disease.;Tuddenham;Br J Haematol,1982

2. Stabilization of factor VIII in plasma by the von Willebrand factor. Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand’s disease.;Weiss;J Clin Invest,1977

3. Biochemistry and genetics of von Willebrand factor.;Sadler;Annu Rev Biochem,1998

4. The genetic basis of von Willebrand disease.;Goodeve;Blood Rev,2010

5. A pH-regulated dimeric bouquet in the structure of von Willebrand factor.;Zhou;EMBO J,2011

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