Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner-Reference-Cited by-同舟云学术

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner

Published:2014-05-15 Issue:20 Volume:123 Page:3105-3115
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Shao Lijian¹,Feng Wei¹,Li Hongliang¹²,Gardner David¹,Luo Yi¹,Wang Yong³,Liu Lingbo³,Meng Aimin²,Sharpless Norman E.⁴,Zhou Daohong¹

Affiliation:

1. Division of Radiation Health, Department of Pharmaceutical Sciences and Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR;

2. Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences (PUMC & CAMS), Tianjin, China;

3. Department of Pathology, Medical University of South Carolina, Charleston, SC; and

4. Department of Medicine and Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC

Abstract

Key Points Total body irradiation causes long-term bone marrow suppression by selectively inducing HSC senescence. The induction of HSC senescence is independent of telomere shortening and p16Ink4a and Arf.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/20/3105/1376498/3105.pdf

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