The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells-Reference-Cited by-同舟云学术

The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells

Published:2014-05-08 Issue:19 Volume:123 Page:2988-2996
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhang Jenny¹²,Jima Dereje¹,Moffitt Andrea B.¹,Liu Qingquan¹,Czader Magdalena³,Hsi Eric D.⁴,Fedoriw Yuri⁵,Dunphy Cherie H.⁵,Richards Kristy L.⁵,Gill Javed I.⁶,Sun Zhen¹,Love Cassandra¹,Scotland Paula¹,Lock Eric⁷,Levy Shawn⁸,Hsu David S.¹²,Dunson David⁷,Dave Sandeep S.¹²⁹

Affiliation:

1. Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC;

2. Duke Cancer Institute, Duke University Medical Center, Durham NC;

3. Indiana University, Indianapolis IN;

4. Cleveland Clinic, Cleveland OH;

5. University of North Carolina, Chapel Hill, NC;

6. Baylor University Medical Center, Dallas, TX;

7. Department of Statistical Science, Duke University, Durham, NC;

8. Hudson Alpha Institute for Biotechnology, Huntsville, AL; and

9. Department of Medicine, Duke University, Durham, NC

Abstract

Key Points We identified novel recurrently mutated genes, including WHSC1, RB1, POT1, and SMARCA4, through exome sequencing of 56 cases of MCL. Genetic mutations defining MCL and Burkitt lymphoma were associated with the epigenetically defined chromatin state of their respective B cells of origin.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/19/2988/1375796/2988.pdf

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