Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis-Reference-Cited by-同舟云学术

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis

Published:2014-02-13 Issue:7 Volume:123 Page:1098-1101
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wildhagen Karin C. A. A.¹,García de Frutos Pablo²,Reutelingsperger Chris P.¹,Schrijver Roy¹,Aresté Cristina²,Ortega-Gómez Almudena³,Deckers Niko M.¹,Hemker H. Coenraad⁴,Soehnlein Oliver³⁵⁶,Nicolaes Gerry A. F.¹

Affiliation:

1. Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands;

2. Department of Cell Death and Proliferation, Institute of Biomedical Research of Barcelona, Barcelona, Spain;

3. Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, Germany;

4. Synapse BV, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands;

5. Department of Pathology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands; and

6. German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany

Abstract

Key PointsNonanticoagulant heparin is shown to bind histones and provide cytoprotection in mouse models of sterile inflammation and sepsis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/7/1098/538024/1098.pdf

Reference15 articles.

1. Current insights in sepsis: from pathogenesis to new treatment targets.;Wiersinga;Curr Opin Crit Care,2011

2. Neutrophil extracellular traps kill bacteria.;Brinkmann;Science,2004

3. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood.;Clark;Nat Med,2007

4. Extracellular histones are major mediators of death in sepsis.;Xu;Nat Med,2009

5. Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones.;Saffarzadeh;PLoS ONE,2012

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