VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice-Reference-Cited by-同舟云学术

VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice

Published:2014-01-02 Issue:1 Volume:123 Page:141-148
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Savchenko Alexander S.¹²,Borissoff Julian I.¹²,Martinod Kimberly¹³,De Meyer Simon F.¹²,Gallant Maureen¹,Erpenbeck Luise¹²,Brill Alexander¹²,Wang Yanming⁴,Wagner Denisa D.¹²⁵

Affiliation:

1. Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA;

2. Department of Pediatrics, and

3. Immunology Graduate Program, Division of Medical Sciences, Harvard Medical School, Boston, MA;

4. Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA; and

5. Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA

Abstract

Key Points PAD4-mediated chromatin decondensation and release by neutrophils exacerbate injury after MI/R. Combining reduction of neutrophil recruitment with extracellular DNA cleavage could be a new approach to reduce cardiac damage after MI.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/1/141/1373759/141.pdf

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3. Myocardial infarction and the open-artery hypothesis.;Hillis;N Engl J Med,2006

4. Lethal reperfusion injury in acute myocardial infarction: facts and unresolved issues.;Garcia-Dorado;Cardiovasc Res,2009

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