mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation-Reference-Cited by-同舟云学术

mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation

Published:2016-08-04 Issue:5 Volume:128 Page:615-624
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Yang Jun¹,Zhou Xuan¹²,Fan Xiaorong¹,Xiao Min¹,Yang Dinghua³,Liang Bo³,Dai Meng⁴,Shan Lanlan⁴,Lu Jingbo⁵,Lin Zhiqi⁵,Liu Rong⁶,Liu Jun⁷,Wang Liping⁸⁹,Zhong Mei⁸,Jiang Yu⁹,Bai Xiaochun¹^ORCID

Affiliation:

1. State Key Laboratory of Organ Failure Research, Department of Cell Biology, School of Basic Medical Sciences,

2. Department of Hematology, Zhujiang Hospital,

3. Department of Hepatobiliary Surgery, Nanfang Hospital,

4. Department of Health Management Center, Nanfang Hospital,

5. Department of Vascular Surgery, Nanfang Hospital, and

6. Health Management Center, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China;

7. Department of Urology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China;

8. Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China; and

9. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA

Abstract

Key Points Activation of mTORC1 in MKs and platelets contributes to aging-related venous thrombosis. ROS production with aging activates mTORC1 to elevate MPV and platelet activation and promote venous thrombosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/5/615/1397943/615.pdf

Reference47 articles.

1. Risk of venous thromboembolism associated with peripherally inserted central catheters: a systematic review and meta-analysis.;Chopra;Lancet,2013

2. Factor XI antisense oligonucleotide for venous thrombosis.;Büller;N Engl J Med,2015

3. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study.;Silverstein;Arch Intern Med,1998

4. Age-related changes in thrombosis and hemostasis.;Kwaan;Semin Thromb Hemost,2014

5. Aging and thrombosis.;Wilkerson;Semin Thromb Hemost,2002

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