Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment-Reference-Cited by-同舟云学术

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

Published:2013-08-01 Issue:5 Volume:122 Page:749-758
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mussai Francis¹,De Santo Carmela¹,Abu-Dayyeh Issa¹,Booth Sarah¹,Quek Lynn²,McEwen-Smith Rosanna M.¹,Qureshi Amrana³,Dazzi Francesco⁴,Vyas Paresh²,Cerundolo Vincenzo¹

Affiliation:

1. Medical Research Council Human Immunology Unit and

2. Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom;

3. Department of Paediatric Oncology, Children’s Hospital, John Radcliffe Hospital, Oxford, United Kingdom; and

4. Department of Haematology, Hammersmith Hospital, London, United Kingdom

Abstract

Key Points AML blasts have an arginase-dependent ability to inhibit T-cell proliferation and hematopoietic stem cells. AML blasts have an arginase-dependent ability to modulate the polarization of monocytes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/5/749/1373507/749.pdf

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