Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy-Reference-Cited by-同舟云学术

Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy

Published:2016-05-19 Issue:20 Volume:127 Page:2406-2410
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Gardner Rebecca¹²,Wu David³,Cherian Sindhu³,Fang Min³,Hanafi Laïla-Aïcha⁴,Finney Olivia¹,Smithers Hannah¹,Jensen Michael C.¹²,Riddell Stanley R.⁴⁵,Maloney David G.⁴⁵,Turtle Cameron J.⁴⁵

Affiliation:

1. Seattle Children’s Research Institute,

2. Department of Pediatrics, and

3. Department of Laboratory Medicine, University of Washington, Seattle, WA;

4. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; and

5. Department of Medicine, University of Washington, Seattle, WA

Abstract

Key Points CD19-targeted CAR-T-cell therapy of patients with MLL-rearranged B-ALL effectively induced marrow remission of B-ALL. Patients with MLL-rearranged B-ALL who attain CR after CD19 CAR-T-cell therapy may be at risk for relapse with clonally related AML.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/20/2406/1393485/2406.pdf

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4. Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.;Sotillo;Cancer Discov,2015

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