ICAM-1–expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia

Author:

Woodfin Abigail1,Beyrau Martina1,Voisin Mathieu-Benoit1,Ma Bin1,Whiteford James R.1,Hordijk Peter L.2,Hogg Nancy3,Nourshargh Sussan1

Affiliation:

1. William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom;

2. Sanquin Research and Landsteiner Laboratory, Swammerdam Institute for Life Sciences Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; and

3. Leukocyte Adhesion Laboratory, Cancer Research UK London Research Institute, London, United Kingdom

Abstract

Key PointsMurine neutrophils can be stimulated by LPS to express de novo ICAM-1 in vitro and in murine models of endotoxemia in vivo. Neutrophil ICAM-1 expression correlated with enhanced phagocytosis and ROS generation, and ICAM-1 deficiency caused defective phagocytosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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4. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).;Dustin;J Immunol,1986

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