Stromal cell–mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling

Author:

Jitschin Regina1,Braun Martina1,Qorraj Mirjeta1,Saul Domenica1,Le Blanc Katarina2,Zenz Thorsten34,Mougiakakos Dimitrios1

Affiliation:

1. Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany;

2. Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden;

3. Department of Translational Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany; and

4. Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany

Abstract

Key Points Stromal cells promote a glycolytic switch in CLL cells in a Notch-c-Myc signaling-dependent manner. Targeting glucose metabolism or the Notch-c-Myc signaling pathway could be exploited to breach stromal cell–mediated CLL drug resistance.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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