UKALLXII/ECOG2993: addition of imatinib to a standard treatment regimen enhances long-term outcomes in Philadelphia positive acute lymphoblastic leukemia

Author:

Fielding Adele K.1,Rowe Jacob M.2,Buck Georgina3,Foroni Letizia4,Gerrard Gareth4,Litzow Mark R.5,Lazarus Hillard6,Luger Selina M.7,Marks David I.8,McMillan Andrew K.9,Moorman Anthony V.10,Patel Bella1,Paietta Elisabeth11,Tallman Martin S.12,Goldstone Anthony H.1

Affiliation:

1. University College London, London, United Kingdom;

2. Rambam Medical Center, Haifa, Israel;

3. Clinical Trial Service Unit, Oxford, United Kingdom;

4. Imperial Molecular Pathology Laboratory, Hammersmith Hospital, London, United Kingdom;

5. Mayo Clinic, Rochester, MN;

6. University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH;

7. University of Pennsylvania Abramson Cancer Center, Philadelphia, PA;

8. University Hospitals Bristol National Health Service Trust, Bristol, United Kingdom;

9. Nottingham University Hospitals, Nottingham, United Kingdom;

10. Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, United Kingdom;

11. Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY; and

12. Memorial Sloane Kettering Cancer Center, New York, NY

Abstract

Key Points Imatinib improves outcomes for adults with Ph+ ALL at least in part by facilitating allogeneic stem cell transplant. Allogeneic hematopoietic stem cell transplant is not dispensible in Ph+ ALL in the imatinib era.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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