Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study

Author:

Crump Michael1,Neelapu Sattva S.2,Farooq Umar3,Van Den Neste Eric4,Kuruvilla John1,Westin Jason2,Link Brian K.3,Hay Annette1,Cerhan James R.5,Zhu Liting1,Boussetta Sami4,Feng Lei2,Maurer Matthew J.5,Navale Lynn6,Wiezorek Jeff6,Go William Y.6,Gisselbrecht Christian4

Affiliation:

1. Canadian Cancer Trials Group, Queen’s University, Kingston, ON, Canada;

2. Division of Cancer Medicine, Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX;

3. Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Internal Medicine, University of Iowa, Iowa City, IA;

4. Lymphoma Academic Research Organization, Pierre-Bénite, France;

5. Department of Health Sciences Research, Mayo Clinic, Rochester, MN; and

6. Kite Pharma, Santa Monica, CA

Abstract

Key Points SCHOLAR-1 is the first patient-level analysis of outcomes of refractory DLBCL from 2 large randomized trials and 2 academic databases. SCHOLAR-1 demonstrated poor outcomes in patients with refractory DLBCL, supporting a need for more effective therapies for these patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference37 articles.

1. 2016 US lymphoid malignancy statistics by World Health Organization subtypes [published online ahead of print 12 September 2016];Teras;CA Cancer J Clin

2. Diffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up;Tilly;Ann Oncol,2012

3. Survival for haematological malignancies in Europe between 1997 and 2008 by region and age: results of EUROCARE-5, a population-based study;Sant;Lancet Oncol,2014

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