Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

Author:

Boudreau Luc H.1,Duchez Anne-Claire1,Cloutier Nathalie1,Soulet Denis2,Martin Nicolas3,Bollinger James4,Paré Alexandre2,Rousseau Matthieu1,Naika Gajendra S.4,Lévesque Tania1,Laflamme Cynthia1,Marcoux Geneviève1,Lambeau Gérard5,Farndale Richard W.6,Pouliot Marc1,Hamzeh-Cognasse Hind7,Cognasse Fabrice7,Garraud Olivier7,Nigrovic Peter A.8,Guderley Helga3,Lacroix Steve2,Thibault Louis9,Semple John W.10,Gelb Michael H.4,Boilard Eric1

Affiliation:

1. Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculté de Médecine de l’Université Laval, Département de Microbiologie et Immunologie, Quebec, QC, Canada;

2. Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculté de Médecine de l’Université Laval, Département de Psychiatrie et Neurosciences, Quebec, QC, Canada;

3. Département de Biologie, Université Laval, Quebec, QC, Canada;

4. Department of Chemistry, University of Washington, Seattle, WA;

5. Institut de Pharmacologie Moléculaire et Cellulaire, Unité Mixte de Recherche 7275, Centre National de la Recherche Scientifique-Université Nice Sophia Antipolis, Valbonne, France;

6. Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom;

7. Etablissement Français du Sang Auvergne-Loire and Université de Lyon, Saint-Etienne, France;

8. Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA;

9. Research and Development, Héma-Québec, Quebec, QC, Canada; and

10. The Keenan Research Center in the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON, Canada

Abstract

Key Points When activated and in platelet storage bags, platelets release respiratory-competent mitochondria, a recognized damage-associated molecular pattern. Mitochondria, descendant of Rickettsia prowazekii, serve as substrate for bactericidal sPLA2-IIA to promote inflammation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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